Benefits of drinking coffee in women drinking coffee can reduce the risk of postmenopausal breast and endometrial cancer

Coffee intake reduces postmenopausal breast cancer risk

Objective: A dose-response meta-analysis was performed to summarize evidence for an association between coffee intake and breast cancer risk from prospective cohort studies.

Methods: A systematic search was performed in the electronic database as of March 2017 to identify relevant studies; risk estimates were retrieved from the studies and linear and nonlinear dose response analyses using a constrained cubic spline model were performed. Stratified and subgroup analyses were performed by menopause and estrogen/progesterone receptor (ER/PR) status, smoking status, and body mass index (BMI) to detect potential confounders.

Results: A total of 21 prospective studies were selected for dose-response, highest and lowest consumption categories, or subgroup analyses. Dose-response analyses of 13 prospective studies showed no significant association between coffee intake and breast cancer risk in nonlinear models. However, when the analysis was limited to postmenopausal women, the opposite relationship was found. Drinking four cups of coffee a day was associated with a 10% reduction in postmenopausal cancer risk (relative risk, RR 0.90;95% confidence interval, CI 0.82 to 0.99). Subgroup analyses showed consistent results for all potential confounders.

Coffee lowers risk of endometrial cancer

Objective: The aim of this study was to conduct a meta-analysis of the association between coffee consumption and endometrial cancer risk.

Methods: Eligible studies were identified by searching PubMed and EMBASE databases. Dose-response relationships between the highest and lowest coffee consumption categories and endometrial cancer risk were assessed. Subgroup analyses considering menopause and receptor status, smoking status, and BMI (body mass index) were performed to identify potential confounders.

Results: A total of 12 studies eligible for meta-analysis were identified. A dose-response meta-analysis showed a reduced risk of endometrial cancer. In addition, subgroup analyses showed that coffee consumption was significantly associated with a reduced postmenopausal cancer risk. Increasing coffee intake by four cups per day was associated with a 20% reduction in endometrial cancer risk (RR 0.80;95% CI 0.72 to 0.89) and a 24% reduction in postmenopausal cancer risk (RR 0.76;95% CI 0.69 to 0.83).

Conclusions: The results suggest that increased coffee intake is associated with a reduced risk of endometrial cancer, and that this association may also apply to postmenopausal cancer.